Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease
نویسندگان
چکیده
منابع مشابه
Neurofibrillary Tangles of Aβx-40 in Alzheimer's Disease Brains.
The two pathognomonic lesions in the brain of AD patients are senile plaques and intraneuronal neurofibrillary tangles (NFT). Previous studies have demonstrated that amyloid-β (Aβ) is a component of both senile plaques and NFTs, and have showed that intracellular accumulation of Aβ is toxic for cells and precedes the appearance of extracellular amyloid deposits. Here we report that there are nu...
متن کاملPhosphorylated neurofilament antigens in neurofibrillary tangles in Alzheimer's disease.
Neurofibrillary tangles (NFT) are a hallmark of Alzheimer's disease (AD), and their presence correlates with the presence of dementia. A major constituent of NFT is the insoluble paired helical filament which shares some antigenic relationships with normal cytoskeletal elements, particularly neurofilaments. If neurofilament proteins (200, 145-160, and 68 kilodaltons [kd]) participate in the for...
متن کاملNeurofibrillary tangles in nondemented elderly subjects and mild Alzheimer disease.
BACKGROUND The relationship between neuropathological lesions and mild, "preclinical," cognitive impairments of Alzheimer disease is poorly understood. Identification of the lesions that are most closely associated with the earliest symptoms of Alzheimer disease is crucial to the understanding of the disease process and the development of treatment strategies to affect its progression. DESIGN...
متن کاملEstrogen receptor-α is localized to neurofibrillary tangles in Alzheimer’s disease
The female predominance for developing Alzheimer disease (AD) suggests the involvement of gender specific factor(s) such as a reduced estrogen-estrogen receptor signaling in the pathogenesis of AD. The potential role of ERα in AD pathogenesis has been explored by several groups with mixed results. We revisited this issue of expression and distribution of ERα in AD brain using a specific ERα ant...
متن کاملIs there a spatial association between senile plaques and neurofibrillary tangles in Alzheimer's disease?
OBJECTIVE To test the hypothesis that the clusters of senile plaques (SP) and neurofibrillary tangles (NFT) in patients with Alzheimer's disease (AD) are spatially associated as predicted by the 'Amyloid Cascade Hypothesis'. METHODS The spatial association between the SP and NFT was studied in the cerebral cortex and hippocampus in six cases of sporadic Alzheimer's disease (AD) using continge...
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ژورنال
عنوان ژورنال: Molecular Neurodegeneration
سال: 2008
ISSN: 1750-1326
DOI: 10.1186/1750-1326-3-13